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1

Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain

Sekiguchi, Fumiko, Kawara, Yuma, Tsubota, Maho, Kawakami, Eri, Ozaki, Tomoka, Kawaishi, Yudai, Tomita, Shiori, Kanaoka, Daiki, Yoshida, Shigeru, Ohkubo, Tsuyako, Kawabata, Atsufumi

Journal:

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

2

Effects of somatosensory cortical stimulation on expression of c-Fos in rat medullary dorsal horn in response to formalin-induced noxious stimulation

Fusami Gojyo, Shinichi Sugiyo, Ryotaro Kuroda, Atsufumi Kawabata, Vidya Varathan, Yoshio Shigenaga, Motohide Takemura

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 376 KB

english, 2002

3

Involvement of Voltage-Gated Calcium Channels in Inflammation and Inflammatory Pain

Sekiguchi, Fumiko, Tsubota, Maho, Kawabata, Atsufumi

Journal:

Biological & Pharmaceutical Bulletin

Year:

2018

Language:

english

File:

PDF, 2.44 MB

english, 2018

4

Antinociceptive effect of L-arginine on the carrageenin-induced hyperalgesia of the rat: possible involvement of central opioidergic systems

Atsufumi Kawabata, Yukiko Fukuzumi, Yoshimi Fukushima, Hiroshi Takagi

Journal:

European Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 456 KB

english, 1992

5

Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice

Murakami-Nakayama, Masahiro, Tsubota, Maho, Hiruma, Saki, Sekiguchi, Fumiko, Matsuyama, Kenji, Kimura, Takeshi, Moriyama, Masahiro, Kawabata, Atsufumi

Journal:

Journal of Pharmacological Sciences

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

6

Involvement of NF-κB in the upregulation of cystathionine-γ-lyase, a hydrogen sulfide-forming enzyme, and bladder pain accompanying cystitis in mice

Ozaki, Tomoka, Tsubota, Maho, Sekiguchi, Fumiko, Kawabata, Atsufumi

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2017

Language:

english

File:

PDF, 800 KB

english, 2017

7

Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains

Hayashi, Yusuke, Tsujita, Ryuichi, Tsubota, Maho, Saeki, Haruka, Sekiguchi, Fumiko, Honda, Goichi, Kawabata, Atsufumi

Journal:

Biochemical and Biophysical Research Communications

Year:

2017

Language:

english

File:

PDF, 1.11 MB

english, 2017

8

Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice

Tomita, Shiori, Sekiguchi, Fumiko, Deguchi, Tomoyo, Miyazaki, Takaya, Ikeda, Yuya, Tsubota, Maho, Yoshida, Shigeru, Du Nguyen, Huy, Okada, Takuya, Toyooka, Naoki, Kawabata, Atsufumi

Journal:

Year:

2018

Language:

english

File:

PDF, 516 KB

english, 2018

9

ChemInform Abstract: The G Protein-Coupled Protease Receptor PAR (Protease-Activated Receptor) as a Novel Target for Drug Development

Atsufumi Kawabata

Journal:

Year:

2001

File:

PDF, 25 KB

2001

10

2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice

Atsufumi Kawabata, Yuko Oono, Daiki Yonezawa, Kaori Hiramatsu, Naoki Inoi, Fumiko Sekiguchi, Masami Honjo, Michiko Hirofuchi, Toru Kanke, Hiroyuki Ishiwata

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 174 KB

english, 2005

11

Mechanisms for prostaglandin E2 formation caused by proteinase-activated receptor-1 activation in rat gastric mucosal epithelial cells

Fumiko Sekiguchi, Shino Saito, Kaori Takaoka, Hitomi Hayashi, Mami Nagataki, Keita Nagasawa, Hiroyuki Nishikawa, Hirofumi Matsui, Atsufumi Kawabata

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 1003 KB

english, 2007

12

SPECIAL REPORT Evidence that endogenous nitric oxide modulates plasma fibrinogen levels in the rat

Atsufumi Kawabata

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 441 KB

english, 1996

13

Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice

Kazumasa Okubo, Midori Matsumura, Yudai Kawaishi, Yuka Aoki, Maho Matsunami, Yasumasa Okawa, Fumiko Sekiguchi, Atsufumi Kawabata

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 897 KB

english, 2012

14

l-Leucyl-l-arginine, naltrindole and d-arginine block antinociception elicited by l-arginine in mice with carrageenin-induced hyperalgesia

Atsufumi Kawabata, Yumiko Nishimura, Hiroshi Takagi

Journal:

British Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.07 MB

english, 1992

15

Hydrogen sulfide and neuronal differentiation: Focus on Ca2+ channels

Fukami, Kazuki, Kawabata, Atsufumi

Journal:

Year:

2015

Language:

english

File:

PDF, 706 KB

english, 2015

16

10.1254/fpj.128.82

Kawabata, Atsufumi

Journal:

Folia Pharmacologica Japonica

Year:

2006

File:

PDF, 394 KB

2006

17

Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle

Kubo, Satoko, Doe, Ichiko, Kurokawa, Yuko, Kawabata, Atsufumi

Journal:

Journal of Pharmacological Sciences

Year:

2007

Language:

english

File:

PDF, 430 KB

english, 2007

18

Lipopolysaccharide-induced subsensitivity of protease-activated receptor-2 in the mouse salivary glands in vivo

Atsufumi Kawabata, Ryotaro Kuroda, Nao Morimoto, Naoyuki Kawao, Takashi Masuko, Kazuaki Kakehi, Kazuo Kataoka, Mamoru Taneda, Hiroyuki Nishikawa, Hiromasa Araki

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

19

Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice

Atsufumi Kawabata, Maho Matsunami, Masahiro Tsutsumi, Tsuyoshi Ishiki, Osamu Fukushima, Fumiko Sekiguchi, Naoyuki Kawao, Takeshi Minami, Toru Kanke, Naohiro Saito

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 212 KB

english, 2006

20

Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide

Atsufumi Kawabata, Ryotaro Kuroda, Hiroyuki Nishikawa, Toshiharu Asai, Kazuo Kataoka, Mamoru Taneda

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 178 KB

english, 1999

21

Roles of urokinase type plasminogen activator in a brain stab wound

Kazuo Kataoka, Toshiharu Asai, Mamoru Taneda, Shigeru Ueshima, Osamu Matsuo, Ryotaro Kuroda, Atsufumi Kawabata, Peter Carmeliet

Journal:

Year:

2000

Language:

english

File:

PDF, 404 KB

english, 2000

22

L-Tyrosine-induced antinociception in the mouse: involvement of central δ-opioid receptors and bulbo-spinal noradrenergic system

Atsufumi Kawabata, Kazuyo Kasamatsu, Hiroshi Takagi

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 532 KB

english, 1993

23

Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat

Yoshihisa Kamanaka, Atsufumi Kawabata, Hidekazu Matsuya, Chiyomi Taga, Fumiko Sekiguchi, Naoyuki Kawao

Journal:

Year:

2003

Language:

english

File:

PDF, 282 KB

english, 2003

24

Role of Thrombin in Soluble Thrombomodulin-Induced Suppression of Peripheral HMGB1-Mediated Allodynia in Mice

Tsujita, Ryuichi, Tsubota, Maho, Hayashi, Yusuke, Saeki, Haruka, Sekiguchi, Fumiko, Kawabata, Atsufumi

Journal:

Journal of Neuroimmune Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.70 MB

english, 2017

25

Repeated Cold Stress Enhances the Acute Restraint Stress-Induced Hyperthermia in Mice

Miyamoto, Tomoyoshi, Funakami, Yoshinori, Kawashita, Erika, Nomura, Ai, Sugimoto, Nanako, Saeki, Haruka, Tsubota, Maho, Ichida, Seiji, Kawabata, Atsufumi

Year:

2017

Language:

english

File:

PDF, 639 KB

english, 2017

26

Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers

Du Nguyen, Huy, Okada, Takuya, Kitamura, Shun, Yamaoka, Sakura, Horaguchi, Yamato, Kasanami, Yoshihito, Sekiguchi, Fumiko, Tsubota, Maho, Yoshida, Shigeru, Nishikawa, Hiroyuki, Kawabata, Atsufumi, Toy

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.21 MB

english, 2018

27

ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis

Takahiro Miki, Maho Matsunami, Saori Nakamura, Hiroki Okada, Hidekazu Matsuya, Atsufumi Kawabata

Journal:

Year:

2011

Language:

english

File:

PDF, 1.13 MB

english, 2011

28

Central antinociceptive effect of l-ornithine, a metabolite of l-arginine, in rats and mice

Atsufumi Kawabata, Katsumi Iwatsubo, Shinji Takaya, Hiroshi Takagi

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 775 KB

english, 1996

29

Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms

Atsufumi Kawabata, Yumiko Nakaya, Tsuyoshi Ishiki, Satoko Kubo, Ryotaro Kuroda, Fumiko Sekiguchi, Naoyuki Kawao, Hiroyuki Nishikawa, Kenzo Kawai

Journal:

Year:

2004

Language:

english

File:

PDF, 339 KB

english, 2004

30

Gastrointestinal functions of proteinase-activated receptors

Atsufumi Kawabata

Journal:

Year:

2003

Language:

english

File:

PDF, 202 KB

english, 2003

31

Roles of Ca v 3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis

Terada, Yuka, Fujimura, Mayuko, Nishimura, Sachiyo, Tsubota, Maho, Sekiguchi, Fumiko, Kawabata, Atsufumi

Journal:

Journal of Neuroscience Research

Year:

2015

Language:

english

File:

PDF, 630 KB

english, 2015

32

Changes of tissue blood flow in mice loaded with SART (repeated cold) stress or restraint and water immersion stress and the effect of administered neurotropin.

HATA, Taeko, KITA, Tomitaro, KAWABATA, Atsufumi, ITOH, Eiji, NISHIMURA, Yoshitaka

Journal:

The Japanese Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 822 KB

english, 1986

33

Mechanism of the analgesic effect of neurotropin.

HATA, Taeko, KITA, Tomitaro, ITOH, Eiji, OYAMA, Ritsuko, KAWABATA, Atsufumi

Journal:

The Japanese Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 648 KB

english, 1988

34

Changes in platelet count and related parameters in SART-stressed mice and the action of administered neurotropin.

HATA, Taeko, KAWABATA, Atsufumi, KITA, Tomitaro, ITOH, Eiji, NISHIMURA, Yoshitaka

Journal:

The Japanese Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 472 KB

english, 1988

35

Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2

Toru Kanke, Hiroyuki Ishiwata, Mototsugu Kabeya, Masako Saka, Takeshi Doi, Yukio Hattori, Atsufumi Kawabata, Robin Plevin

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

36

Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats

Hiroyuki Nishikawa, Kenzo Kawai, Sachiyo Nishimura, Shuichi Tanaka, Hiromasa Araki, Bahjat Al-Ani, Morley D Hollenberg, Ryotaro Kuroda, Atsufumi Kawabata

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 173 KB

english, 2002

37

The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents

Hiroyasu Ishikura, Sachiyo Nishimura, Maho Matsunami, Toshifumi Tsujiuchi, Tsuyoshi Ishiki, Fumiko Sekiguchi, Mitsuhide Naruse, Toshio Nakatani, Yoshihisa Kamanaka, Atsufumi Kawabata

Journal:

Year:

2007

Language:

english

File:

PDF, 821 KB

english, 2007

38

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

Yamasoba, Daichi, Tsubota, Maho, Domoto, Risa, Sekiguchi, Fumiko, Nishikawa, Hiroyuki, Liu, Keyue, Nishibori, Masahiro, Ishikura, Hiroyasu, Yamamoto, Tetsushi, Taga, Atsushi, Kawabata, Atsufumi

Journal:

Journal of Pharmacological Sciences

Year:

2016

Language:

english

File:

PDF, 1.21 MB

english, 2016

39

Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats

Nishida, Takeshi, Tsubota, Maho, Kawaishi, Yudai, Yamanishi, Hiroki, Kamitani, Natsuki, Sekiguchi, Fumiko, Ishikura, Hiroyasu, Liu, Keyue, Nishibori, Masahiro, Kawabata, Atsufumi

Journal:

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

40

Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca v 3.2 in mice

Ozaki, Tomoka, Matsuoka, Junki, Tsubota, Maho, Tomita, Shiori, Sekiguchi, Fumiko, Minami, Takeshi, Kawabata, Atsufumi

Journal:

Year:

2018

Language:

english

File:

PDF, 2.37 MB

english, 2018

41

Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity

Tsubota, Maho, Uebo, Kenta, Miki, Koki, Sekiguchi, Fumiko, Ishigami, Akihiko, Kawabata, Atsufumi

Journal:

Biochemical and Biophysical Research Communications

Year:

2019

File:

PDF, 1.29 MB

2019

42

Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice

Matsui, Kazuki, Terada, Yuka, Tsubota, Maho, Sekiguchi, Fumiko, Kawabata, Atsufumi

Journal:

Journal of Pharmacological Sciences

Year:

2020

File:

PDF, 1.37 MB

2020

43

Delayed production of arachidonic acid contributes to the delay of proteinase-activated receptor-1 (PAR1)-triggered prostaglandin E2 release in rat gastric epithelial RGM1 cells

Fumiko Sekiguchi, Ai Ohi, Yuma Maeda, Kaori Takaoka, Teruki Sekimoto, Hiroyuki Nishikawa, Prof. Atsufumi Kawabata

Journal:

Journal of Cellular Biochemistry

Year:

2011

Language:

english

File:

PDF, 297 KB

english, 2011

44

Determination of Mucin in Salivary Glands Using Sialic Acids as the Marker by High-Performance Liquid Chromatography with Fluorometric Detection

Atsufumi Kawabata, Nao Morimoto, Yasuo Oda, Mitsuhiro Kinoshita, Ryotaro Kuroda, Kazuaki Kakehi

Journal:

Analytical Biochemistry

Year:

2000

Language:

english

File:

PDF, 46 KB

english, 2000

45

Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide

Takeshi Tarui, Kazuki Fukami, Keita Nagasawa, Shigeru Yoshida, Fumiko Sekiguchi, Atsufumi Kawabata

Journal:

Journal of Neurochemistry

Year:

2010

Language:

english

File:

PDF, 498 KB

english, 2010

46

Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channels

Keita Nagasawa, Takeshi Tarui, Shigeru Yoshida, Fumiko Sekiguchi, Maho Matsunami, Ai Ohi, Kazuki Fukami, Seiji Ichida, Hiroyuki Nishikawa, Atsufumi Kawabata

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 623 KB

english, 2009

47

Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion

Naoyuki Kawao, Yuriko Sakaguchi, Ai Tagome, Ryotaro Kuroda, Shozo Nishida, Kiyohiro Irimajiri, Hiroyuki Nishikawa, Kenzo Kawai, Morley D Hollenberg, Atsufumi Kawabata

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 220 KB

english, 2002

48

The proteinase/proteinase-activated receptor-2/transient receptor potential vanilloid-1 cascade impacts pancreatic pain in mice

Sachiyo Nishimura, Hiroyasu Ishikura, Maho Matsunami, Yui Shinozaki, Fumiko Sekiguchi, Mitsuhide Naruse, Taisuke Kitamura, Ryukichi Akashi, Kenji Matsumura, Atsufumi Kawabata

Journal:

Year:

2010

Language:

english

File:

PDF, 1.60 MB

english, 2010

49

Impact of a Pharmacist-Implemented Anemia Management in Outpatients with End-Stage Renal Disease in Japan

Kimura, Takeshi, Arai, Mamiko, Masuda, Hiroya, Kawabata, Atsufumi

Journal:

Biological & Pharmaceutical Bulletin

Year:

2004

Language:

english

File:

PDF, 132 KB

english, 2004

50

The G Protein-Coupled Protease Receptor PAR (Protease-Activated Receptor) as a Novel Target for Drug Development.

KAWABATA, Atsufumi

Journal:

YAKUGAKU ZASSHI

Year:

2001

File:

PDF, 347 KB

2001

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